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Science 3 October 1969:
Vol. 166. no. 3901, pp. 121 - 122
DOI: 10.1126/science.166.3901.121
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Articles

Adenosine Triphosphatase Sensitive to DDT in Synapses of Rat Brain

Fumio Matsumura 1 and K. C. Patil 1

1 Department of Entomology, University of Wisconsin, Madison 53706

The insecticide DDT selectively inhibits the action of a Na+, K+, Mg2+-adenosine triphosphatase found in the nerve ending fraction of the rat brain. As judged by the concentrations of inhibitors that give 50 percent of enzyme inhibition, DDT was approximately 1000 times more toxic than its non-insecticidal analog, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene. The degrees of inhibition of this enzyme system by various toxic and nontoxic DDT analogs were closely related to a general toxicity in vivo of these compounds. Moreover, the extents of inhibition of this enzyme system by DDT were much higher at low temperatures, an indication of a causal relation between poisoning in vivo by DDT and the inhibition in vitro of the Na+, K+, Mg2+-adenosine triphosphatase system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DDT: Inhibition of Sodium Chloride Tolerance by the Blue-Green Alga Anacystis nidulans.
J. C. Battertc, G. M. Bous, and F. Matsumur (1972)
Science 176, 1141-1143
   Abstract »    PDF »
DDT: Disrupted Osmoregulatory Events in the Intestine of the Eel Anguilla rostrata Adapted to Seawater.
R. H. Janicki and W. B. Kinter (1971)
Science 173, 1146-1148
   Abstract »    PDF »
DDT: Participation in Ultraviolet-Detectable, Charge-Transfer Complexation.
W. E. Wilson, L. Fishbein, and S. T. Clements (1971)
Science 171, 180-182
   Abstract »    PDF »
Antagonism by DDT of the Effect of Valinomycin on a Synthetic Membrane.
B. D. Hilton and R. D. O'Brien (1970)
Science 168, 841-843
   Abstract »    PDF »


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