Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 September 1969:
Vol. 165. no. 3900, pp. 1371 - 1372
DOI: 10.1126/science.165.3900.1371
Prev | Table of Contents | Next

Articles

Cytochrome P-420: Tubular Aggregates from Hepatic Microsomes

D. W. Shoeman 1, J. G. White 2, and G. J. Mannering 3

1 Department of Pharmacology, College of Medical Sciences, University of Minnesota, Minneapolis 55455
2 Department of Pediatrics, University of Minnesota
3 Department of Pharmacology, University of Minnesota

Aggregates were formed when clear supernatants from hepatic microsomes that had been treated with steapsin were desalted and concentrated. These aggregates contain large numbers of uniform tubular elements. These structures resemble microtubules seen in many cells but differ in their substructure. The aggregates were rich in cytochrome P-420. Unlike soluble cytochrome P-420, the cytochrome P-420 contained in the aggregates combines with drugs to give the characteristic difference spectra normally seen only with cytochrome P-450 contained in intact microsomes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ultrastructural Features of Erythrocyte and Hemoglobin Sickling.
J. G. White (1974)
Arch Intern Med 133, 545-562
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)