Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 September 1969:
Vol. 165. no. 3899, pp. 1262 - 1264
DOI: 10.1126/science.165.3899.1262
Prev | Table of Contents | Next

Articles

Diphosphonates Inhibit Hydroxyapatite Dissolution in vitro and Bone Resorption in Tissue Culture and in vivo

Herbert Fleisch 1, R. Graham 1, G. Russell 1, and Marion D. Francis 2

1 Department of Pathophysiology, University of Berne, Switzerland and Laboratory for Experimental Surgery, Davos, Switzerland
2 Miami Valley Laboratories, The Procter & Gamble Company, Cincinnati, Ohio 45239

Two diphosphonates containing the P-C-P bond, Cl2C(PO3HNa)2, and H2C(PO3HNa)2 retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bisphosphonates in Oncology: Rising Stars or Fallen Heroes.
T. Van den Wyngaert, M. T. Huizing, E. Fossion, and J. B. Vermorken (2009)
Oncologist 14, 181-191
   Abstract »    Full Text »    PDF »
Disambiguating the bisphosphonates.
T. Van den Wyngaert, M. T. Huizing, and J. B. Vermorken (2008)
Ann. Onc. 19, 1357-1359
   Full Text »    PDF »
Bisphosphonates: Mode of Action and Pharmacology.
R. G. G. Russell (2007)
Pediatrics 119, S150-S162
   Abstract »    Full Text »    PDF »
Use of bisphosphonates to improve the durability of total joint replacements..
A. S. Shanbhag (2006)
J. Am. Acad. Ortho. Surg. 14, 215-225
   Abstract »    Full Text »    PDF »
A prospective randomized controlled clinical trial of zoledronic acid for bone metastases.
K. Mystakidou, E. Katsouda, E. Parpa, E. Kouskouni, C. Chondros, M. L. Tsiatas, A. Galanos, and L. Vlahos (2006)
American Journal of Hospice and Palliative Medicine 23, 41-50
   Abstract »    PDF »
Bisphosphonates and atherosclerosis: why?.
M Bevilacqua, L J Dominguez, S Rosini, and M Barbagallo (2005)
Lupus 14, 773-779
   Abstract »    PDF »
Discovery, Clinical Development, and Therapeutic Uses of Bisphosphonates.
A. A Licata (2005)
Ann. Pharmacother. 39, 668-677
   Abstract »    Full Text »    PDF »
SUPRAGINGIVAL CALCULUS: FORMATION AND CONTROL.
Y. Jin and H.-K. Yip (2002)
Critical Reviews in Oral Biology & Medicine 13, 426-441
   Abstract »    Full Text »    PDF »
A Phase I Dose-ranging Trial of Monthly Infusions of Zoledronic Acid for the Treatment of Osteolytic Bone Metastases.
J. R. Berenson, R. A. Vescio, L. S. Rosen, J. M. VonTeichert, M. Woo, R. Swift, A. Savage, E. Givant, M. Hupkes, H. Harvey, et al. (2001)
Clin. Cancer Res. 7, 478-485
   Abstract »    Full Text »
Short- and Long-Term Effects of Ibandronate Treatment on Bone Turnover in Paget Disease of Bone.
H. W. Woitge, H. Oberwittler, S. Heichel, A. Grauer, R. Ziegler, and M. J. Seibel (2000)
Clin. Chem. 46, 684-690
   Abstract »    Full Text »    PDF »
Farnesol and Geranylgeraniol Prevent Activation of Caspases by Aminobisphosphonates: Biochemical Evidence for Two Distinct Pharmacological Classes of Bisphosphonate Drugs.
H. L. Benford, J. C. Frith, S. Auriola, J. Mönkkönen, and M. J. Rogers (1999)
Mol. Pharmacol. 56, 131-140
   Abstract »    Full Text »
Bisphosphonates: Mechanisms of Action.
H. Fleisch (1998)
Endocr. Rev. 19, 80-100
   Abstract »    Full Text »
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development.
J. H. Lin and A. Y. H. Lu (1997)
Pharmacol. Rev. 49, 403-449
   Abstract »    Full Text »    PDF »
Short-Term Effects of Pamidronate in Patients with Gaucher's Disease and Severe Skeletal Involvement.
G. Ciana, M. Cuttini, and B. Bembi (1997)
N. Engl. J. Med. 337, 712
   Full Text »
Short-Term Variations in Bone Remodeling Biochemical Markers: Cyclical Etidronate and Alendronate Effects Compared.
P. Bettica, M. Bevilacqua, T. Vago, M. Masino, E. Cucinotta, and G. Norbiato (1997)
J. Clin. Endocrinol. Metab. 82, 3034-3039
   Abstract »    Full Text »    PDF »
The Management of Paget's Disease of Bone.
P. D. Delmas and P. J. Meunier (1997)
N. Engl. J. Med. 336, 558-566
   Full Text »    PDF »
"Have You Seen This?" Bone Anti-Resorptive Properties of Bisphosphonates.
J. Hartke (1996)
Toxicol Pathol 24, 799-800
   PDF »
Developmental Disturbances of the Rat Molar Induced By Two Diphosphonates.
N. Fouda, M. Caracatsanis, and L. Hammarstrom (1989)
Advances in Dental Research 3, 234-240
   Abstract »    PDF »
Effects of a New Aminodiphosphonate (Aminohydroxybutylidene Diphosphonate) in Patients With Osteolytic Lesions From Metastases and Myelomatosis: Comparison With Dichloromethylene Diphosphonate.
G. Attardo-Parrinello, G. Merlini, F. Pavesi, F. Crema, M. L. Fiorentini, and E. Ascari (1987)
Arch Intern Med 147, 1629-1633
   Abstract »    PDF »
Inhibitory Effect of Inositol Phosphates on Parathyroid Hormone-induced Bone Resorption in Organ Cultures.
B.C. Gomes, H.W. Kaufman, J.R. Bloom, J. Navon, T.J. Wilkens, and R.A. Rifkin (1984)
Journal of Dental Research 63, 890-893
   Abstract »    PDF »
Drugs Five Years Later: Etidronate Disodium in the Treatment of Paget's Disease of Bone.
S. M. KRANE (1982)
Ann Intern Med 96, 619-625
   Abstract »    PDF »
Steady-state relationship of calcium-45 between bone and blood: differences in growing dogs, chicks, and rats.
L Klein (1981)
Science 214, 190-193
   Abstract »    PDF »
Dynamics of Enamel Formation in the Rat Incisor Tooth.
C.P. Leblond and H. Warshawsky (1979)
Journal of Dental Research 58, 950-979
   Abstract »    PDF »
Chemical Prevention of Calculus Formation in the Rat.
G. K. Stookey and J. L. McDonald jr (1974)
Journal of Dental Research 53, 1334-1337
   Abstract »    PDF »
Organic Polymeric Polyphosphonates as Potential Preventive Agents of Dental Caries : In Vitro Experiments.
M. Anbar, G.A. St. John, and A.C. Scott (1974)
Journal of Dental Research 53, 867-878
   Abstract »    PDF »
Myositis Ossificans Progressiva: Effect of Intravenously Given Parathyroid Extract on Urinary Excretion of Connective Tissue Components.
J. H. Bland, B. Kirschbaum, G. T. O'Connor, and E. Whorton (1973)
Arch Intern Med 132, 209-212
   Abstract »    PDF »
Synthetic Salmon Calcitonin: Treatment of Paget's Disease and Osteogenesis Imperfecta.
E. B. Goldfield, B. M. Braiker, J. J. Prendergast, and F. O. Kolb (1972)
JAMA 221, 1127-1129
   Abstract »    PDF »
A Review of the Physiological and Pharmacological Effects of Pyrophosphate and Diphosphonates on Bones and Teeth.
H. Fleisch and R.G.G. Russell (1972)
Journal of Dental Research 51, 323-332
   PDF »
Diphosphonate Therapy in a Patient with Myositis Ossificans Progressiva.
I. W. WEISS, L. FISHER, and J. M. PHANG (1971)
Ann Intern Med 74, 933-936
   Abstract »    PDF »
Uremic Toxins and Mineral Metabolism: Potential Sites of Interaction.
H. J. Gitelman (1970)
Arch Intern Med 126, 793-800
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)