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Science 12 September 1969:
Vol. 165. no. 3898, pp. 1134 - 1137
DOI: 10.1126/science.165.3898.1134
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Articles

Tumor Induction in Developing Frog Kidneys by a Zonal Centrifuge Purified Fraction of the Frog Herpes-Type Virus

Merle Mizell 1, Irv Toplin 2, and J. Joyce Isaacs 3

1 Chapman H. Hyams III Laboratory of Tumor Cell Biology, Tulane University, New Orleans, Louisiana 70118
2 John L. Smith Memorial for Cancer Research, Chas. Pfizer Co., Inc., Maywood, New Jersey 07607
3 Chapman H. Hyams III Laboratory of Tumor Cell Biology

Injection of frog embryos (Rana pipiens) with a zonal centrifuge purified fraction of herpes-type virus (prepared from virus-containing Lucké tumors) resulted in a high incidence of kidney tumors. This partially purified oncogenic fraction contained a high concentration of an enveloped form of the frog herpes-type virus (adjacent fractions lacked this particle and were not oncogenic), which suggests that this form of the virus plays a role in the genesis of the Lucké tumor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Virus-Free Adenocarcinoma of the Frog (Summer Phase Tumor) Transcribes Lucke Tumor Herpesvirus-Specific RNA.
W. Collard, H. Thornton, M. Mizell, and M. Green (1973)
Science 181, 448-449
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)