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Science 5 September 1969:
Vol. 165. no. 3897, pp. 1025 - 1027
DOI: 10.1126/science.165.3897.1025
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Articles

Erythropoiesis in the Dog: The Periodic Nature of the Steady State

Alec Morley 1 and Frederick Stohlman Jr. 1

1 St. Elizabeth's Hospital, Tufts University School of Medicine, Boston, Massachusetts

In at least six of 11 normal dogs serial measurement of reticulocyte counts showed oscillation with a period of approximately 14 days. The phase of oscillation could be altered by bleeding followed by retransfusion. The observations suggest that canine erythropoiesis is an example of a physiological rhythm which has its origin in homeostatic control.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)