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Science 5 September 1969:
Vol. 165. no. 3897, pp. 1018 - 1020
DOI: 10.1126/science.165.3897.1018
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Articles

Cyclic Adenosine Monophosphate: Possible Mediator for Norepinephrine Effects on Cerebellar Purkinje Cells

George R. Siggins 1, Barry J. Hoffer 1, and Floyd E. Bloom 1

1 Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

Microelectrophoretic application of norepinephrine or cyclic adenosine monophosphate reduces the discharge frequency of Purkinje cells in the rat cerebellum. In contrast, other nucleotides accelerate the discharge rate of most units. Parenterally administered theophylline, which inhibits the hydrolysis of cyclic adenosine monophosphate enhances the effects of norepinephrine and cyclic adenosine monophosphate. Therefore, norepinephrine may be able to regulate Purkinje cells functionally by metabolic stimulation of cyclic adenosine monophosphate synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Floyd Bloom: the next editor-in-chief of Science.
R. Lerner and R Guillemin (1995)
Science 267, 1441-1442
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Analogs of cyclic adenosine monophosphate: correlation of inhibition of Purkinje Neurons with Protein Kinase Activation.
G. Siggins and S. Henriksen (1975)
Science 189, 559-561
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Dopamine receptors in the brain.
L. Iversen (1975)
Science 188, 1084-1089
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Interpreting the Failures to Confirm the Depression of Cerebellar Purkinje Cells by Cyclic AMP.
F. E. Bloom, G. R. Siggins, and B. J. Hopper (1974)
Science 185, 627-629
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Octopamine-Sensitive Adenylate Cyclase: Evidence for a Biological Role of Octopamine in Nervous Tissue.
J. A. Nathanson and P. Greengard (1973)
Science 180, 308-310
   Abstract »    PDF »
Noradrenergic Stimulation of Cyclic Adenosine Monophosphate in Rat Purkinje Neurons: An Immunocytochemical Study.
G. R. Siggins, E. F. Battenberg, B. J. Hoffer, F. E. Bloom, and A. L. Steiner (1973)
Science 179, 585-588
   Abstract »    PDF »
Adenosine 3',5'-Monophosphate: Electrophysiological Evidence for a Role in Synaptic Transmission.
D. A. McAfee and P. Greengard (1972)
Science 178, 310-312
   Abstract »    PDF »
Cyclic Adenosine Monophosphate and Norepinephrine: Effect on Purkinje Cells in Rat Cerebellar Cortex.
J. M. Godfraind, R. Pumain, G. R. Siggins, B. J. Hoffer, and F. E. Bloom (1971)
Science 174, 1257-1259
   PDF »
Cyclic Adenosine Monophosphate: Function in Photoreceptors.
W. H. Miller, R. E. Gorman, and M. W. Bitensky (1971)
Science 174, 295-297
   Abstract »    PDF »
Distribution of Cyclic Adenosine Monophosphate in Rat Brain.
M. S. Ebadi, B. Weiss, and E. Costa (1971)
Arch Neurol 24, 353-357
   Abstract »    PDF »
Cyclic Adenosine and Guanosine Monophosphates and Glucagon: Effect on Liver Membrane Potentials.
N. Friedmann, A. V. Somlyo, and A. P. Somlyo (1971)
Science 171, 400-402
   Abstract »    PDF »
Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells.
G. R. Siggins, A. P. Oliver, B. J. Hoffer, and F. E. Bloom (1971)
Science 171, 192-194
   Abstract »    PDF »
Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity.
J. L. Barker, J. W. Crayton, and R. A. Nicoll (1971)
Science 171, 208-210
   Abstract »    PDF »
Prostaglandins E1 and E2 Antagonize Norepinephrine Effects on Cerebellar Purkinje Cells: Microelectrophoretic Study.
B. J. Hoffer, G. R. Siggins, and F. E. Bloom (1969)
Science 166, 1418-1420
   Abstract »    PDF »


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