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Science 5 September 1969:
Vol. 165. no. 3897, pp. 1013 - 1014
DOI: 10.1126/science.165.3897.1013
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Articles

Hormonal Stimulation of Lactose Synthetase in Mammary Carcinoma

William L. McGuire 1

1 Endocrinology Branch, National Cancer Institute, Bethesda, Maryland 20014

A transplantable rat mammary carcinoma (R3230AC) synthesizes significant quantities of the mammary gland enzyme lactose synthetase in the immature virgin female rat. In this hormonal environment, mammary glands do not synthesize the enzyme. Prolactin further stimulates the enzyme activity in the tumors to levels found only in mammary glands of rats in late pregnancy or during lactation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)