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Science 29 August 1969:
Vol. 165. no. 3896, pp. 911 - 913
DOI: 10.1126/science.165.3896.911
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Articles

Quantal Secretion from Adrenal Medulla: All-or-None Release of Storage Vesicle Content

O. H. Viveros 1, L. Arqueros 1, and N. Kirshner 2

1 Institute of Physiology, Faculty of Medicine, University of Chile, Santiago
2 Department of Biochemistrv, Duke University Medical Center, Durham, North Carolina 27706

Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-beta-hydroxylase activity and the catecholamine content of the storage vesicle fraction. After sedimentation through a sucrose density gradient, the storage vesicles obtained from insulin-treated animals had the same density and the same ratio of dopamine-beta-hydroxylase to catecholamine as did vesicles from untreated animals. These and other data indicate that neurogenic secretion from the adrenal medulla occurs by an all-or-none release from the storage vesicles.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)