Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 August 1969:
Vol. 165. no. 3896, pp. 909 - 910
DOI: 10.1126/science.165.3896.909
Prev | Table of Contents | Next

Articles

Maturation of Renal Organic Acid Transport: Substrate Stimulation by Penicillin

G. H. Hirsch 1 and J. B. Hook 1

1 Department of Pharmacology, Michigan State University, East Lansing 48823

Renal p-aminohippurate transport in rabbits increased rapidly from birth to 4 weeks of age and then declined to that observed in adults. Penicillin administration to pregnant does or newborn rabbits stimulated the developing transport system, but did not increase the peak observed at 4 weeks. Therefore the continued presence of substrate (penicillin) during development significantly enhances the rate of maturation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Developing Kidney and Environmental Toxins.
M. J. Solhaug, P. M. Bolger, and P. A. Jose (2004)
Pediatrics 113, 1084-1091
   Abstract »    Full Text »    PDF »
The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?.
S. A. Eraly, K. T. Bush, R. V. Sampogna, V. Bhatnagar, and S. K. Nigam (2004)
Mol. Pharmacol. 65, 479-487
   Abstract »    Full Text »    PDF »
Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney.
G.-H. Kim, K. Y. Na, S.-Y. Kim, K. W. Joo, Y. K. Oh, S.-W. Chae, H. Endou, and J. S. Han (2003)
Nephrol. Dial. Transplant. 18, 1505-1511
   Abstract »    Full Text »    PDF »
Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney.
G.-H. Kim, K. Y. Na, S.-Y. Kim, K. W. Joo, Y. K. Oh, S.-W. Chae, H. Endou, and J. S. Han (2003)
Nephrol. Dial. Transplant. 18, 1505-1511
   Abstract »    Full Text »
The organic anion transporter family: from physiology to ontogeny and the clinic.
D. H. Sweet, K. T. Bush, and S. K. Nigam (2001)
Am J Physiol Renal Physiol 281, F197-F205
   Abstract »    Full Text »    PDF »
Protein kinase C regulation of p-glycoprotein-mediated xenobiotic secretion in renal proximal tubule.
D. S. Miller, C. R. Sussman, and J. L. Renfro (1998)
Am J Physiol Renal Physiol 275, F785-F795
   Abstract »    Full Text »    PDF »
Protein kinase C regulation of organic anion transport in renal proximal tubule.
D. S. Miller (1998)
Am J Physiol Renal Physiol 274, F156-F164
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)