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Science 15 August 1969:
Vol. 165. no. 3894, pp. 700 - 702
DOI: 10.1126/science.165.3894.700
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Articles

Energized Configurations of Heart Mitochondria in situ

Robert A. Harris 1, Charles H. Williams 1, Monya Caldwell 1, David E. Green 1, and Enrique Valdivia 2

1 Institute for Enzyme Research, University of Wisconsin, Madison 53706
2 Department of Pathology, University of Wisconsin, Madison 53706

Changes in the configurational state of the cristal membranes of rat heart mitochondria within the living cell can be induced by imposing energizing conditions. An exact correlation has been established between the configurational states of the cristal membrane and the energy states of the mitochondrion. The configurational changes observed in mitochondria in situ are comparable to those established for beef heart mitochondria in vitro and are consistent with the postulate of the conformational basis of energy transductions in membrane systems. The formation of paracrystalline arrays is one of the noteworthy features of configurational changes of mitochondria in situ.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Severe Hypermetabolism with Primary Abnormality of Skeletal Muscle Mitochondria: Functional and Therapeutic Effects of Chloramphenicol Treatment.
N. A. HAYDAR, H. L. CONN JR., A. AFIFI, N. WAKID, S. BALLAS, and K. FAWAZ (1971)
Ann Intern Med 74, 548-558
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Science. ISSN 0036-8075 (print), 1095-9203 (online)