Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 August 1969:
Vol. 165. no. 3893, pp. 616 - 617
DOI: 10.1126/science.165.3893.616
Prev | Table of Contents | Next

Articles

Epinephrine Metabolism in Mammalian Brain after Intravenous and Intraventricular Administration

Alan M. Steinman 1, Stanley E. Smerin 1, and Jack D. Barchas 1

1 Department of Psychiatry, School of Medicine, Stanford University, Stanford, California 94305

Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)