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Science 8 August 1969:
Vol. 165. no. 3893, pp. 609 - 611
DOI: 10.1126/science.165.3893.609
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Articles

Unexpected Adrenergic Effect of Chlorpromazine: Eating Elicited by Injection into Rat Hypothalamus

Sarah Fryer Leibowitz 1 and Neal E. Miller 1

1 Rockefeller University, New York 10021

Although chlorpromazine is believed to block adrenergic transmission, injection of this drug into the hypothalamus of satiated rats does not block norepinephrine-elicited eating, but instead mimics norepinephrine by eliciting eating. The amount of eating elicited by norepinephrine and by chlorpromazine is reliably correlated. These results suggest that endogenous norepinephrine mediates eating elicited by centrally injected chlorpromazine.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)