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Science 8 August 1969:
Vol. 165. no. 3893, pp. 597 - 598
DOI: 10.1126/science.165.3893.597
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Articles

Carcinoma of the Cervix: Deficiency of Nexus Intercellular Junctions

N. Scott McNutt 1 and Ronald S. Weinstein 1

1 James Homer Wright Pathology Laboratories and Mixter Laboratory for Electron Microscopy, Massachusetts General Hospital, Boston 02114

Intercellar junctions where cell membranes are in intimate contact (nexuses) are very abundant in the epithelium of normal human cervix. Squamous carcinoma cells are deficient in nexuses although a rare nexus is seen. Nexuses may be involved in normal growth regulation, while a deficiency of nexuses may be related to the invasive property of malignant growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Arch Dermatol 117, 160-180
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Cell Junctions in Development, with Particular Reference to the Neural Tube.
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Junctions between Cancer Cells in Culture: Ultrastructure and Permeability.
R. G. Johnson and J. D. Sheridan (1971)
Science 174, 717-719
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Science. ISSN 0036-8075 (print), 1095-9203 (online)