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Science 1 August 1969:
Vol. 165. no. 3892, pp. 508 - 509
DOI: 10.1126/science.165.3892.508
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Articles

Neutralization of Sensitized Virus by the Fourth Component of Complement

Charles A. Daniels 1, Tibor Borsos 2, Herbert J. Rapp 2, Ralph Snyderman 3, and Abner Louis Notkins 4

1 Virology Section, Laboratory of Microbiology, National Institute of Dental Research, Bethesda, Maryland 20014
2 Biology Branch, National Cancer Institute
3 Immunology Section, Laboratory of Microbiology, National Institute of Dental Research
4 Virology Section, Laboratory of Microbiology, National Institute of Dental Research

Herpes simplex virus which had been sensitized with IgM antibody was not neutralized by the addition of the purified activated first component of complement. In the presence of an optimum concentration of the first component of complement, however, the sensitized virus was neutralized by the addition of a high concentration of the purified fourth component of complement. Under these conditions, the addition of the purified second and third components of complement failed to enhance virus neutralization. With low concentrations of the fourth component of complement, the addition of the second and third components enhanced virus neutralization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interaction of Rheumatoid Factor with Infectious Herpes Simplex Virus-Antibody Complexes.
W. K. Ashe, C. A. Daniels, G. S. Scott, and A. L. Notkins (1971)
Science 172, 176-177
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Science. ISSN 0036-8075 (print), 1095-9203 (online)