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Science 1 August 1969:
Vol. 165. no. 3892, pp. 496 - 498
DOI: 10.1126/science.165.3892.496

Articles

Estradiol: Specific Binding by Pituitary Nuclear Fraction in vitro

W. W. Leavitt 1, J. P. Friend 1, and J. A. Robinson 1

1 Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219

The nuclear fraction of a homogenate of anterior pituitary has a marked binding affinity for estradiol but not for other hormonal steroids. Characteristics of the uptake of estradiol by pituitary nuclear fraction are like those reported for the uterus. Study in vitro will be useful in elucidating how direct estrogen feedback control of anterior pituitary function is mediated.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pituitary Gonadotrophs: Nuclear Concentration of Radioactivity after Injection of [3H]Testosterone.
M. Sar and W. E. Stumpf (1973)
Science 179, 389-391
   Abstract »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)