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Science 1 August 1969:
Vol. 165. no. 3892, pp. 492 - 493
DOI: 10.1126/science.165.3892.492
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Articles

Indole(ethyl)amine N-Methyltransferase in the Brain

Merrily Morgan 1 and Arnold J. Mandell 1

1 Department of Psychiatry, University of California, San Diego, La Jolla 92037

An enzyme which N-methylates various indole(ethyl)amine substrates was isolated from brain, separated from the pituitary and the pineal glands. It appeared localized in the supernatant and synaptosomal areas after discontinuous sucrose-gradient ultracentrifugation. This is the first demonstration of the enzyme in brain.


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