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Science 1 August 1969:
Vol. 165. no. 3892, pp. 490 - 492
DOI: 10.1126/science.165.3892.490
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Articles

Potentially Lethal Radiation Damage: Repair by Mammalian Cells in Culture

James A. Belli 1 and Merijean Shelton 1

1 Section of Radiation Biology, Department of Radiology, University of Texas Southwestern Medical School, Dallas 75235

Less than optimum conditions with regard to cell division after x-irradiation provide the necessary environment in which mammalian cells can repair potentially lethal radiation damage. The kinetics of repair suggest that, during the repair process, a transient, unstable cellular state occurs which prevents cell division in complete growth medium. The capacity for repair appears to be dependent on cell age.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Mitochondria-targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair.
M. S. RAJAGOPALAN, K. GUPTA, M. W. EPPERLY, D. FRANICOLA, X. ZHANG, H. WANG, H. ZHAO, V. A. TYURIN, J. G. PIERCE, V. E. KAGAN, et al. (2009)
In Vivo 23, 717-726
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Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase Cells.
Y.-C. Lio, D. Schild, M. A. Brenneman, J. L. Redpath, and D. J. Chen (2004)
J. Biol. Chem. 279, 42313-42320
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