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Science 18 July 1969:
Vol. 165. no. 3890, pp. 304 - 306
DOI: 10.1126/science.165.3890.304
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Articles

Virus-like Antigen, Antibody, and Antigen-Antibody Complexes in Hepatitis Measured by Complement Fixation

N. Raphael Shulman 1 and Lewellys F. Barker 2

1 Clinical Hematology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014
2 Laboratory of Viral Immunology, Division of Biological Standards, National Institutes of Health

Complement fixation techniques are described for measuring a virus-like antigen associated with viral hepatitis. Antigen was found in the blood of 98 percent of 130 patients, with the serum form of hepatitis, from whom multiple samples were obtained. Antibodies arising during hepatitis are usually combined with antigen and cause anticomplementary activity in the serum, which is reversible with excess antigen or antibody. Tests for antigen and specific anticomplementary activity can be used diagnostically and to screen blood donors for hepatitis carriers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transmission of Serum Hepatitis.
L. F. Barker, N. R. Shulman, R. Murray, R. J. Hirschman, F. Ratner, W. C. L. Diefenbach, and H. M. Geller (1996)
JAMA 276, 841-844
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The Liver and the Antigens of Hepatitis B.
G. L. GITNICK, L. S. GOLDBERG, R. KORETZ, and J. H. WALSH (1976)
Ann Intern Med 85, 488-496
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{alpha}1-Fetoprotein and Liver-Specific Antigen in Viral Hepatitis Type B.
J. B. Smith and L. F. Barker (1974)
Arch Intern Med 133, 437-439
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Antibody Responses in Viral Hepatitis, Type B.
L. F. Barker, M. R. Peterson, N. R. Shulman, and R. Murray (1973)
JAMA 223, 1005-1008
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Anicteric Hepatitis Presenting as Polyarthritis.
D. P. Stevens, J. Walker, E. Crum, H. P. Roth, and R. W. Moskowitz (1972)
JAMA 220, 687-689
   Abstract »    PDF »
Coincidental Australia Antigenemia in Primary Biliary Cirrhosis.
W. C. MADDREY, S. SAITO, N. R. SHULMAN, and G. KLATSKIN (1972)
Ann Intern Med 76, 705-709
   Abstract »    PDF »
Virus-like Particles Within Hepatocytes of Australia Antigen Carriers.
F. Caramia, C. De Bac, and G. Ricci (1972)
Arch Pediatr Adolesc Med 123, 309-311
   Abstract »    PDF »
Australia Antigen in Africans: An Anatomic, Clinical, and Immunologic Study.
G. Saimot, D. Menache, N. Schlegel, and M. Payet (1972)
Arch Pediatr Adolesc Med 123, 410-411
   Abstract »    PDF »
A Serological Survey for Australia Antigen and Antibody.
S. J. Newman, D. L. Madden, G. L. Gitnick, and J. L. Sever (1971)
Arch Pediatr Adolesc Med 122, 129-133
   Abstract »    PDF »
Arthritis of Hepatitis Associated with Australia Antigen.
D. K. ONION, C. S. CRUMPACKER, and B. C. GILLILAND (1971)
Ann Intern Med 75, 29-33
   Abstract »    PDF »
Aquisition Of Hepatitis-Associated Antigen: Clinical Features in Young Adults.
L. F. Barker and R. Murray (1971)
JAMA 216, 1970-1976
   Abstract »    PDF »
Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis.
G. N. Vyas and N. R. Shulman (1970)
Science 170, 332-333
   Abstract »    PDF »
Serum Hepatitis Antigen (SH): Rapid Detection by High Voltage Immunoelectroosmophoresis.
A. M. Prince and K. Burke (1970)
Science 169, 593-595
   Abstract »    PDF »
Rapid Screening Test for Detecting Hepatitis-Associated Antigen.
C. A. Saravis, C. Trey, and G. F. Grady (1970)
Science 169, 298-299
   Abstract »    PDF »
Viral Hepatitis: New Light on an Old Disease.
S. Krugman and J. P. Giles (1970)
JAMA 212, 1019-1029
   Abstract »    PDF »
Transmission of Serum Hepatitis.
L. F. Barker, N. R. Shulman, R. Murray, R. J. Hirschman, F. Ratner, W. C. L. Diefenbach, and H. M. Geller (1970)
JAMA 211, 1509-1512
   Abstract »    PDF »
Asymptomatic Cytomegalovirus Infection Following Blood Transfusion in Tumor Surgery.
D. P. Stevens, L. F. Barker, A. S. Ketcham, and H. M. Meyer Jr. (1970)
JAMA 211, 1341-1344
   Abstract »    PDF »
Viral Hepatitis.
N. R. SHULMAN, R. J. HIRSCHMAN, and L. F. BARKER (1970)
Ann Intern Med 72, 257-269
   Abstract »    PDF »


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