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Science 18 July 1969:
Vol. 165. no. 3890, pp. 297 - 298
DOI: 10.1126/science.165.3890.297
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Articles

Chloramphenicol: Effects on Mouse Myeloma Cells in Tissue Culture

Boyd K. Hartman 1, Olive S. Pettengill 1, and George D. Sorenson 1

1 Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110

Within 36 hours of being administered, chloramphenicol (50 micrograms per milliliter) inhibits by 50 percent the rate of protein synthesis in mouse myeloma cells grown in suspension culture. Although there is a decrease in the amount of globulin synthesized, the rate of synthesis per cell is unchanged; the observed decrease is traced to the inhibition of cell proliferation caused by chloramphenicol.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)