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Science 11 July 1969:
Vol. 165. no. 3889, pp. 191 - 192
DOI: 10.1126/science.165.3889.191
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Articles

Cyclophosphamide: Effect on Experimental Allergic Encephalomyelitis in Lewis Rats

Philip Y. Paterson 1 and Diane G. Drobish 1

1 Samuel J. Sackett Research Laboratories and Infectious Diseases-Hypersensitivity Section, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611

Lewis rats sensitized to spinal cord in adjuvant and exhibiting advanced clinical paralytic signs of experimental allergic encephalomyelitis were treated with cyclophosphamide (5 milligrams per kilogram) daily. Of 30 treated animals, 21 recovered rapidly and appeared clinically well within 7 to 12 days. This immunosuppressive agent may prove therapeutically useful in the treatment of autoimmune diseases.


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