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Science 4 July 1969:
Vol. 165. no. 3888, pp. 65 - 67
DOI: 10.1126/science.165.3888.65
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Articles

Aspirin: Its Effect on Platelet Glycolysis and Release of Adenosine Diphosphate

J. C. G. Doery 1, J. Hirsh 1, and G. C. de Gruchy 1

1 University of Melbourne, Department of Medicine, St. Vincent's Hospital, Melbourne, Australia

Incubation of human platelets with aspirin inhibited glycolysis and produced a fall in the concentration of adenosine triphosphate. When platelets were exposed to collagen there was an increase in glycolysis and release of adenosine diphosphate. Prior incubation of the platelets with aspirin for 5 minutes did not totally suppress the increase in glycolysis after exposure to collagen but completely inhibited the collagen-induced reaction of the release of adenosine diphosphate. It is suggested that aspirin acts on human platelets by inhibiting both release of adenosine diphosphate and the transport of glucose across the platelet membrane.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aspirin: The Unique Drug.
D. G. Friend (1974)
Arch Surg 108, 765-769
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