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Science 27 June 1969:
Vol. 164. no. 3887, pp. 1530 - 1532
DOI: 10.1126/science.164.3887.1530
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Articles

Generation of Adrenergic and Cholinergic Potentials in Sympathetic Ganglion Cells

Benjamin Libet 1 and Haruo Kobayashi 1

1 Department of Physiology, University of California School of Medicine, San Francisco 94122

Norepinephrine elicited a hyperpolarizing response, and acetylcholine (during nicotinic blockade) elicited a depolarizing one. Both responses showed no increase in membrane conductance. The norepinephrine response was suppressed by initial depolarization; the acetylcholine response (frog cells); by hyperpolarization. These neurotransmitters apparently can activate electrogenic mechanisms which do not involve movement of ions down their electrochemical gradients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acetylcholine Responses in L Cells.
P. G. Nelson and J. H. Peacock (1972)
Science 177, 1005-1007
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Science. ISSN 0036-8075 (print), 1095-9203 (online)