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Science 27 June 1969:
Vol. 164. no. 3887, pp. 1527 - 1529
DOI: 10.1126/science.164.3887.1527
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Articles

Chromatin and Histones: Binding of Tritiated Actinomycin D to Heterochromatin in Mealy Bugs

Laurence Berlowitz 1, Dominick Pallotta 1, and Carol H. Sibley 1

1 Department of Biology, State University of New York, Buffalo

The degree of actinomycin D binding to DNA in chromatin is dependent upon the state of repression of chromatin. Living cells bind three times more tritiated actinomycin to euchromatin than to genetically inactive heterochromatin. Extraction of histone results in a general increase in tritiated actinomycin binding and in a ratio of the uptake in heterochromatin to that in euchromatin approaching unity.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)