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Science 27 June 1969:
Vol. 164. no. 3887, pp. 1524 - 1525
DOI: 10.1126/science.164.3887.1524
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Articles

Limited Periods of Gene Expression in Immunoglobulin-Synthesizing Cells

Donald N. Buell 1 and John L. Fahey 1

1 Immunology Branch, National Cancer Institute, Bethesda, Maryland

In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Quantitative Aspects of Plasma Membrane-Associated Immunoglobulin in Clones of Diploid Human Lymphocytes.
R. A. Lerner, P. J. McConahey, and F. J. Dixon (1971)
Science 173, 60-62
   Abstract »    PDF »
Immunoglobulin Production by Human Lymphocytoid Lines and Clones: Absence of Genic Exclusion.
A. D. Bloom, K. W. Choi, and B. J. Lamb (1971)
Science 172, 382-383
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)