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Science 20 June 1969:
Vol. 164. no. 3886, pp. 1423 - 1425
DOI: 10.1126/science.164.3886.1423
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Articles

Protective Effect of Antilymphocyte Serum on Mice Infected with Plasmodium berghei

John N. Sheagren 1 and Anthony P. Monaco 2

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
2 Boston City Hospital, and Harvard Medical School, Boston, Massachusetts

Rabbit antiserum to mouse lymphocytes prolonged the survival of mice infected with Plasmodium berghei. Since antilymphocyte serum has a well-defined, potent immunosuppressive effect, the immune response of the host to the parasite actually may contribute to the death of the animal with an acute malarial infection.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)