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Science 20 June 1969:
Vol. 164. no. 3886, pp. 1415 - 1417
DOI: 10.1126/science.164.3886.1415
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Articles

Immune Specific Induction of Interferon Production in Cultures of Human Blood Lymphocytes

Jon A. Green 1, Sidney R. Cooperband 1, and Sidney Kibrick 1

1 Departments of Microbiology and Medicine, Boston University School of Medicine, Boston, Massachusetts 02118

Human blood lymphocytes stimulated with nonviral antigens in vitro produce an antiviral substance with the biological and biochemical characteristics of interferon. The induced response was specific for cells obtained from immune donors. Cells from nonimmune donors did not produce interferon on exposure to these substances. The quantity of interferon produced by antigen stimulation was related to concentration of antigen over a relatively narrow range; with higher concentrations induction was decreased. Interferon production was maximum during days 4 to 7 in culture. In contrast, phytohemagglutinin-induced interferon was primarily produced during the first 4 days in culture.


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