Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 May 1969:
Vol. 164. no. 3883, pp. 1082 - 1083
DOI: 10.1126/science.164.3883.1082
Prev | Table of Contents | Next

Articles

Antiserum to Lymphocytes and Procarbazine Compared as Immunosuppressants in Mice

P. Brian Stewart 1 and Vivian Cohen 1

1 Pharma-Research Canada Ltd., 250 Hymus Boulevard, Pointe Claire, Montreal, Canada

As an immunosuppressant procarbazine was as potent as an antiserum to lymphocytes in mice. Both agents significantly prolonged survivals of skin allografts by 4 to 6 weeks. At the maximum tolerated dosage, procarbazine suppressed both circulating hemagglutinins to sheep erythrocytes and plaque-forming cells in the spleen. The antiserum to lymphocytes reduced the numbers of circulating hemagglutinins and plaque-forming cells by 94 percent. Procarbazine was administered to mice for 3 weeks before their exposure to antigen. Exposure for only 9 days, commencing 48 hours before injection of sheep erythrocytes, was less effective in suppressing the titers of hemagglutinins.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)