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Science 30 May 1969:
Vol. 164. no. 3883, pp. 1075 - 1077
DOI: 10.1126/science.164.3883.1075
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Articles

Stability of Asymmetric Phospholipid Membranes

Demetrios Papahadjopoulos 1 and Shinpei Ohki 1

1 Departments of Biochemistry and Biophysics, State University of New York at Buffalo, Buffalo 14214

Bilayers (black films) composed of phosphatidylserine are unstable under conditions of asymmetric distribution of calcium or hydrogen ions with respect to the membrane. Addition of calcium ions to the solution (100 millimolar sodium chloride, pH 7.0) on one side only, produces lowering of the direct-current resistance and results in breaking of the membrane. However, with calcium ions on both sides the membranes are stable and show very high electrical resistance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular mechanisms and forces involved in the adhesion and fusion of amphiphilic bilayers.
C. Helm, J. Israelachvili, and P. McGuiggan (1989)
Science 246, 919-922
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Science. ISSN 0036-8075 (print), 1095-9203 (online)