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Science 30 May 1969:
Vol. 164. no. 3883, pp. 1072 - 1073
DOI: 10.1126/science.164.3883.1072
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Articles

Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression

Arthur G. Steinberg 1 and Israel Rostenberg 1

1 Case Western Reserve University, Cleveland, Ohio 44106

More protein is required to detect the Inv(1) antigen carried in the light chain of immunoglobulin G molecules when the light chain is combined with a ggr2 heavy chain than when it is combined with a ggr1 or ggr3 heavy chain. One of the four ggr2 heavy chains used in the experiment, however, was as efficient as the ggr1 and ggr3 chains, indicating that there may be two subtypes of ggr2. Inv(1) was more easily detected in one of the two light chains used in the experiment. This difference may be associated with the subtypes of the kappa chain derived from studies of the variable portion of the chain.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)