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Science 23 May 1969:
Vol. 164. no. 3882, pp. 955 - 957
DOI: 10.1126/science.164.3882.955
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Articles

Visualization of Nucleolar Genes

O. L. Miller Jr. 1 and Barbara R. Beatty 1

1 Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

The presence of extrachromosomal nucleoli in amphibian oocytes has permitted isolation and electron microscopic observation of the genes coding for ribosomal RNA precursor molecules. Visualization of these genes is possible because many precursor molecules are simultaneously synthesized on each gene. Individual genes are separated by stretches of DNA that apparently are not transcribed at the time of synthesis of precursor rRNA in the extrachromosomal nucleoli.


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