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Science 23 May 1969:
Vol. 164. no. 3882, pp. 952 - 954
DOI: 10.1126/science.164.3882.952
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Articles

Cell Population Kinetics: A Modified Interpretation of the Graph of Labeled Mitoses

A. Ian Hamilton 1

1 Department of Operative Dentistry and Department of Biological Structure, University of Washington, Seattle 98105

Graphs of labeled mitoses, derived from autoradiographs of cell populations with 3H-thymidine, show depressions in the curves at their midpoints. These depressions reflect interruption of DNA synthesis midway through S phase. Such interruptions revealed by the method of labeled mitoses should be considered when determining cell-cycle times.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Temporal coordination of DNA replication with enzyme synthesis in diploid and heteroploid cells..
R. R. Klevecz (1969)
Science 166, 1536-1538
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Science. ISSN 0036-8075 (print), 1095-9203 (online)