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Science 16 May 1969:
Vol. 164. no. 3881, pp. 843 - 845
DOI: 10.1126/science.164.3881.843
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Articles

Membrane Alterations in Hemolysis: Internalization of Plasmalemma Induced by Primaquine

F. L. Ginn 1, P. Hochstein 1, and B. F. Trump 1

1 Departments of Pathology and Physiology antd Pharmacology, Duke University Medical Center, Durham, North Carolina 27706

Incubation of normal human erythrocytes with primaquine, a derivative of 8-aminoquinoline, results in internalization of the cell membrane and the formation of intracellular vacuoles. These changes are similar to those observed in other types of cells in pinocytosis. The reduction in surface cell membrane which accompanies internalization of plasmalemma may be generally significant in the destruction of red cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pathological Alterations of Cation Movements in Red Blood Cells.
J. C. Parker and L. G. Welt (1972)
Arch Intern Med 129, 320-332
   Abstract »    PDF »
Inside-Out Red Cell Membrane Vesicles: Preparation and Puirification.
T. L. Steck, R. S. Weinstein, J. H. Straus, and D. F. H. Wallach (1970)
Science 168, 255-257
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)