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Science 2 May 1969:
Vol. 164. no. 3879, pp. 577 - 580
DOI: 10.1126/science.164.3879.577
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Articles

Encephalitogenic Protein: Structure

Robert F. Kibler 1, Raymond Shapira 1, Sarah McKneally 1, Julia Jenkins 1, Pamela Selden 1, and Frank Chou 1

1 Department of Medicine (Neurology) and Department of Biochemistry, Emory University, Atlanta, Georgia 30322

Amino acid sequences of encephalitogenic proteins from bovine cord and rabbit brain are reported. The bovine protein contains 45 residues. The rabbit protein is identical except for two isopolar substitutions, a dipeptide and amino acid deletion. Analysis of this protein and a 140-residue myelin basic protein indicates that the smaller protein is a portion of the larger encephalitogen. The larger myelin protein contains at least two encephalitogenic sites.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biological Activity and Synthesis of an Encephalitogenic Determinant.
R. Shapira, F. C-H. Chou, S. McKneally, E. Urban, and R. F. Kibler (1971)
Science 173, 736-738
   Abstract »    PDF »
Experimental Allergic Encephalomyelitis: Synthesis of Disease-Inducing Site of the Basic Protein.
E. H. Eylar, J. Caccam, J. J. Jackson, F. C. Westall, and A. B. Robinson (1970)
Science 168, 1220-1223
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)