Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 May 1969:
Vol. 164. no. 3879, pp. 566 - 567
DOI: 10.1126/science.164.3879.566
Prev | Table of Contents | Next

Articles

Glucagon-Sensitive Adenyl Cylase in Plasma Membrane of Hepatic Parenchymal Cells

Stephen L. Pohl 1, Lutz Birnbaumer 1, and Martin Rodbell 1

1 Laboratory of Nutrition and Endocrinology, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

The plasma membrane of hepatic parenchymal cells contains an adenyl cyclase system that is stimulated by glucagon. Adrenocorticotropin and epinephrine do not stimulate this adenyl cyclase, and very little cyclic phospho-diesterase activity is present in the membrane. These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis.
S. Seino and T. Shibasaki (2005)
Physiol Rev 85, 1303-1342
   Abstract »    Full Text »    PDF »
Significance of Prohormone Convertase 2, PC2, Mediated Initial Cleavage at the Proglucagon Interdomain Site, Lys70-Arg71, to Generate Glucagon.
A. Dey, G. M. Lipkind, Y. Rouille, C. Norrbom, J. Stein, C. Zhang, R. Carroll, and D. F. Steiner (2005)
Endocrinology 146, 713-727
   Abstract »    Full Text »    PDF »
Hormone-Calcium Interactions with the Plasma Membrane of Rat Liver Cells.
L. Shlatz and G. V. Marinetti (1972)
Science 176, 175-177
   Abstract »    PDF »
Digitonin Effects on Photoreceptor Adenylate Cyclase.
M. W. Bitensky, R. E. Gorman, and W. H. Miller (1972)
Science 175, 1363-1364
   Abstract »    PDF »
On the Biological Role of Cyclic AMP.
E. W. Sutherland (1970)
JAMA 214, 1281-1288
   Abstract »    PDF »
Hormone-Sensitive Adenyl Cyclase: Cytochemical Localization in Rat Liver.
L. Reik, G. L. Petzold, J. A. Higgins, P. Greengard, and R. J. Barrnett (1970)
Science 168, 382-384
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)