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Science 2 May 1969:
Vol. 164. no. 3879, pp. 553 - 555
DOI: 10.1126/science.164.3879.553
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Articles

Glycosphingolipids with Lewis Blood Group Activity: Uptake by Human Erythrocytes

Donald M. Marcus 1 and Louise E. Cass 1

1 Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461

The Lewis blood group antigens of the human erythrocyte are acquired from plasma and not synthesized in situ. Although assumed previously to be glycoproteins, tile Lewis antigens in plasma are glycosphingolipids Which are taken up by the the erythrocyte membrane from lipoproteins or from aqueous dispersions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Significance of Individual Point Mutations, T202C and C314T, in the Human Lewis (FUT3) Gene for Expression of Lewis Antigens by the Human alpha (1,3/1,4)-Fucosyltransferase, Fuc-TIII.
A. Elmgren, R. Mollicone, M. Costache, C. Borjeson, R. Oriol, J. Harrington, and G. Larson (1997)
J. Biol. Chem. 272, 21994-21998
   Abstract »    Full Text »    PDF »
Molecular Genetic Analysis of the Human Lewis Histo-blood Group System.
T. Kudo, H. Iwasaki, S. Nishihara, N. Shinya, T. Ando, I. Narimatsu, and H. Narimatsu (1996)
J. Biol. Chem. 271, 9830-9837
   Abstract »    Full Text »    PDF »
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation.
Y. Hannun and R. Bell (1989)
Science 243, 500-507
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)