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Science 18 April 1969:
Vol. 164. no. 3877, pp. 310 - 312
DOI: 10.1126/science.164.3877.310
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Articles

Acute Axonal Dystrophy Caused by Fluorocitrate: The Role of Mitochondrial Swelling

Harold Koenig 1

1 Veterans Administration Research Hospital and Department of Neurology and Psychiatry, Northwestern University Medical School, Chicago, Illinois 60611

Fluorocitrate, a Krebs cycle inhibitor, induices neurons to rapidly expel multitudinous lysosomes, mitochondria, and other cytoplasmic constituents into their axons. After convulsive seizures commence, spectacular axonal balloons develop owing to obstruction of axonal flow by "log jams" of extruded organelles. A swelling of neuronal mitochondria is apparently responsible for the disgorgement of cytoplasmic material into axons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A 90-Day Toxicological Evaluation of Compound 1080 (Sodium Monofluoroacetate) in Sprague-Dawley Rats.
C. T. Eason and P. Turck (2002)
Toxicol. Sci. 69, 439-447
   Abstract »    Full Text »    PDF »
Biochemical Basis for Fluorouracil Neurotoxicity: The Role of Krebs Cycle Inhibition by Fluoroacetate.
H. Koenig and A. Patel (1970)
Arch Neurol 23, 155-160
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)