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Science 11 April 1969:
Vol. 164. no. 3876, pp. 185 - 187
DOI: 10.1126/science.164.3876.185
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Articles

Linkage of Lactate Dehydrogenase B and C Loci in Pigeons

W. H. Zinkham 1, H. Isensee 1, and J. H. Renwick 2

1 Department of Pediatrics, Johns Hopkins Hospital. Baltimore, Maryland 21205
2 Department of Public Health, London School of Hygiene and Tropical Medicine, W. C. J, England

Synthesis of lactate dehydrogenase in somatic and gametic tissues of certain avian and mammalian species is controlled by alleles at three loci, A, B, and C. We report breeding experiments with pigeons that conclusively demonstrate linkage between the B and C structural loci in this species. The most probable recombination fraction is zero, and contiguity is not excluded. The upper 95 percent probability limit is 4.5 percent. This tight linkage of two loci that produce closely similar polypeptides suggests that the loci acquired their separate identities through a duplication event. Further-more, the existence of recognizable B- and C-type polypeptides in both the bird and the mammal suggests that the event and the resulting linkage preceded the separation of these fauna. If so, then the linkage has persisted for a very long time.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytochrome c: immunofluorescent localization of the testis-specific form.
E Goldberg, D Sberna, T. Wheat, G. Urbanski, and E Margoliash (1977)
Science 196, 1010-1012
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Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation.
C. Markert, J. Shaklee, and G. Whitt (1975)
Science 189, 102-114
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Homology of Lactate Dehydrogenase Genes: E Gene Function in the Teleost Nervous System.
G. S. Whitt (1969)
Science 166, 1156-1158
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Science. ISSN 0036-8075 (print), 1095-9203 (online)