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Science 4 April 1969:
Vol. 164. no. 3875, pp. 78 - 79
DOI: 10.1126/science.164.3875.78
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Articles

Lysergic Acid Diethylamide: Dissociation of Its Behavioral and Hyperthermic Actions by DL-agr-Methyl-p-Tyrosine

A. Horita 1 and A. E. Hamilton 1

1 Department of Pharmacology, School of Medicinie, University of Washington, Seattle 98105

Rabbits treated with LSD 25 exhibit characteristic signs of hyper-excitability, increased peripheral sympathetic activity, and hyperthermia. When the rabbits received prior treatment with DL-agr-methyl-p-tyrosine, the excitation and sympathetic actions of LSD 25 were abolished or attenuated, but the hyperthermia was unchanged from that of the controls. Concentrations of norepinephrine in brain stems of treated rabbits were greatly decreased. The excitation of central nervous system and sympathomimetic actions of LSD 25 in the rabbit are apparently mediated by norepinephrine, whereas the hyperthermic action functions. through a nonadrenergic mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dose-Response Study of N,N-Dimethyltryptamine in Humans: I. Neuroendocrine, Autonomic, and Cardiovascular Effects.
R. J. Strassman and C. R. Qualls (1994)
Arch Gen Psychiatry 51, 85-97
   Abstract »    PDF »
Dose-Response Study of N,N-Dimethyltryptamine in Humans: II. Subjective Effects and Preliminary Results of a New Rating Scale.
R. J. Strassman, C. R. Qualls, E. H. Uhlenhuth, and R. Kellner (1994)
Arch Gen Psychiatry 51, 98-108
   Abstract »    PDF »
Extreme Hyperthermia After LSD Ingestion.
S. A. Friedman and S. E. Hirsch (1971)
JAMA 217, 1549-1550
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)