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Science 4 April 1969:
Vol. 164. no. 3875, pp. 68 - 70
DOI: 10.1126/science.164.3875.68
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Articles

Polyoma Virus Gene Activity during Lytic Infection and in Transformed Animal Cells

Malcolm A. Martin 1 and David Axelrod 1

1 Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

Randomly labeled RNA's from animal cells either productively infected or transformed by polyoma virus were used to measure virus DNA transcription. During lytic infection, 50 percent of polyoma virus DNA was expressed. In two different polyoma-transformed hamster cell lines, the same 20 percent of the virus genome was transcribed. About 10 percent of polyoma DNA was expressed in the one mouse transformed cell line examined.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biogenesis and Characterization of SV40 and Polyoma RNAs in Productively Infected Cells.
Y. Aloni (1974)
Cold Spring Harb Symp Quant Biol 39, 165-178
   Abstract »    PDF »
A Simplifying Concept in Tumor Virology: Virus-specific "Pleiotropic Effectors".
R. Weil, C. Salomon, E. May, and P. May (1974)
Cold Spring Harb Symp Quant Biol 39, 381-395
   Abstract »    PDF »
Characteristics of SV40 DNA Transcription during Lytic Infection, Abortive Infection, and in Transformed Mouse Cells.
M. A. Martin (1970)
Cold Spring Harb Symp Quant Biol 35, 833-841
   Abstract »    PDF »
Human Diploid Cell Transformation by DNA Extracted from the Tumor Virus SV40.
S. A. Aaronson and G. J. Todaro (1969)
Science 166, 390-391
   Abstract »    PDF »


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