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Science 28 March 1969:
Vol. 163. no. 3874, pp. 1464 - 1467
DOI: 10.1126/science.163.3874.1464
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Articles

1-dgr9-Tetrahydrocannabinol: Neurochemical and Behavioral Effects in the Mouse

David Holtzman 1, Richard A. Lovelil 1, Jerome H. Jaffe 1, and Daniel X. Freedman 1

1 Department of Psychiatry, University of Chicago, Chicago, Illinois 60637

Administration of pure 1-dgr9-tetrahydrocannabinol to mice had the following dose-dependent nzeurochemical and behavioral effects: a slight but significant increase in concentrations of 5-hydroxytryptamine in whole brain; a decrease in concentration of norepinephrine in brain after administration of low doses and an increase after high doses; diminished spontaneous activity, mloderate hypothermnia, hypersetisitivity to tactile and auditory stimiuli, and ataxia after low doses; and sedation, pronounced hypothermia, and markedly diminished spon taneous activity and reactivity after high doses. The duration of the effects on body temperature and spontaneous activity correlated generally with the changes in brain amines. The characteristic changes in brain amines do not correspond exactly to those observed with other psychotropic drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. Pharmacol. Exp. Ther. 304, 1010-1015
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{Delta}9-Tetrahydrocannabinol in Depressed Patients.
J. Kotin, R. M. Post, and F. K. Goodwin (1973)
Arch Gen Psychiatry 28, 345-348
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Inhibition of Normal Growth by Chronic Administration of Dgr-9-Tetrahydrocannabinol.
F. J. Manning, J. H. Mcdonough Jr., T. F. Elsmore, C. Saller, and F. J. Sodetz (1971)
Science 174, 424-426
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Activity of Dgr8-and Dgr9-Tetrahydrocannabinol and Related Compounds in the Mouse.
H. D. Christensen, R. I. Freudenthal, J. T. Gidley, R. Rosenfeld, G. Boegli, L. Testino, D. R. Brine, C. G. Pitt, and M. E. Wall (1971)
Science 172, 165-167
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Marihuana in Man: Three Years Later.
L. E. Hollister (1971)
Science 172, 21-29
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Psychological Effects of Tetrahydrocannabinol.
I. E. Waskow, J. E. Olsson, C. Salzman, and M. M. Katz (1970)
Arch Gen Psychiatry 22, 97-107
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Science. ISSN 0036-8075 (print), 1095-9203 (online)