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Science 28 March 1969:
Vol. 163. no. 3874, pp. 1458 - 1460
DOI: 10.1126/science.163.3874.1458
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Articles

Lactose Synthetase: Progesterone Inhibition of the Induction of agr-Lactalbumin

Roger W. Turkington 1 and Robert L. Hill 1

1 Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27706

Lactose synthesis in the mammary gland is dependent on the hormonally controlled synthesis of the two protein components of lactose synthetase, agr-lactalbumin and a galactosyltransferase. Prolactin induces the synthesis of both proteins in mammary gland explants treated with insulin and hydrocortisone, but the induction kinetics cannot account for the asynchronous synthesis of the two proteins that are observed in vivo. Progesterone appears to take part in the control of lactose synthesis and acts to repress the formation of agr-lactalbumin throughout pregnancy. At parturition, when the concentration of progesterone in the plasma decreases, the rate of agr-lactalbumin synthesis increases.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)