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Science 28 March 1969:
Vol. 163. no. 3874, pp. 1450 - 1451
DOI: 10.1126/science.163.3874.1450
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Articles

25-Hydroxycholecalciferol: Stimulation of Bone Resorption in Tissue Culture

C. L. Trummel 1, L. G. Raisz 1, J. W. Blunt 2, and H. F. Deluca 2

1 Departments of Dentistry and Dental Research and Pharmacology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620
2 Department of Biochemistry, University of Wisconsin, Madison 53706

25-Hydroxycholecalciferol stimulates release of previously incorporated calcium-45 from fetal rat bones in doses of 0.9 to 27 units per milliliter. This effect cannot be produced by much larger doses of vitamin D3. Comparison of stimulation of bone resorption by 25-hydroxycholecalciferol and parathyroid hormone reveals similarities with respect to time course, dose-response slope, and inhibition by calcitonin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
25-hydroxyvitamin D: autoradiographic evidence of sites of action in epiphyseal cartilage and bone.
F. Wezeman (1976)
Science 194, 1069-1071
   Abstract »    PDF »
Parathyroid hormone and 25-hydroxy vitamin D3: synergistic and antagonistic effects on renal phosphate transport.
J. Puschett and W. Beck Jr (1975)
Science 190, 473-475
   Abstract »    PDF »
1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D3 Active on Bone in Anephric Rats.
M. F. Holick, M. Garabedian, and H. F. DeLuca (1972)
Science 176, 1146-1147
   Abstract »    PDF »
1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture.
L. G. Raisz, C. L. Trummel, M. F. Holick, and H. F. Deluca (1972)
Science 175, 768-769
   Abstract »    PDF »
25-Hydroxycholecalciferol: Direct Effect on Calcium Transport.
E. B. Olson and H. F. Deluca (1969)
Science 165, 405-407
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)