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Science 28 March 1969:
Vol. 163. no. 3874, pp. 1450 - 1451
DOI: 10.1126/science.163.3874.1450
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Articles

25-Hydroxycholecalciferol: Stimulation of Bone Resorption in Tissue Culture

C. L. Trummel 1, L. G. Raisz 1, J. W. Blunt 2, and H. F. Deluca 2

1 Departments of Dentistry and Dental Research and Pharmacology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620
2 Department of Biochemistry, University of Wisconsin, Madison 53706

25-Hydroxycholecalciferol stimulates release of previously incorporated calcium-45 from fetal rat bones in doses of 0.9 to 27 units per milliliter. This effect cannot be produced by much larger doses of vitamin D3. Comparison of stimulation of bone resorption by 25-hydroxycholecalciferol and parathyroid hormone reveals similarities with respect to time course, dose-response slope, and inhibition by calcitonin.


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