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Science 14 March 1969:
Vol. 163. no. 3872, pp. 1225 - 1226
DOI: 10.1126/science.163.3872.1225
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Articles

Early Experiences Accelerate Maturation of the 24-Hour Adrenocortical Rhythm

Robert Ader 1

1 Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620

Rats reared under 12-hour alternating periods of light and dark were killed at times corresponding to the times at which the maximum or minimum plasma corticosterone concentrations occur in mature animals. The characteristic 24-hour adrenocortical rhythm was first observed in rats 21 to 25 days old. In rats handled or stimulated with electric shock, the rhythm developed as early as 16 days.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)