Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 14 March 1969:
Vol. 163. no. 3872, pp. 1207 - 1208
DOI: 10.1126/science.163.3872.1207
Prev | Table of Contents | Next

Articles

Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type

Hugh O. McDevitt 1 and Allen Chinitz 1

1 Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

The immune responses of inbred mice to a related series of three synthetic polypeptide antigens are genetically controlled traits which are closely correlated with the genotype for the major histocompatibility (H-2) locus. All strains of the same H-2 type exhibit the same pattern of immune response, independent of the remainder of a given strain's genetic background. There is marked antigen-specific polymorphism between strains of different H-2 types with respect to their patterns of response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Making the Connection: Antibody Responsiveness and MHC Genes.
J. R. Bennink (2004)
J. Immunol. 173, 1499
   Full Text »    PDF »
HLA Class II Associations With Rheumatic Heart Disease Are More Evident and Consistent Among Clinically Homogeneous Patients.
Y. Guedez, A. Kotby, M. El-Demellawy, A. Galal, G. Thomson, S. Zaher, S. Kassem, and M. Kotb (1999)
Circulation 99, 2784-2790
   Abstract »    Full Text »    PDF »
Chemical Features of Peptide Selection by the Class II Histocompatibility Molecules.
E. R. Unanue (1999)
Am. J. Pathol. 154, 651-664
   Full Text »    PDF »
The Concept of Antigen Processing and Presentation.
E. R. Unanue (1995)
JAMA 274, 1071-1073
   Abstract »    PDF »
Class II Major Histocompatibility Complex on Melanocytes of Vogt-Koyanagi-Harada Disease.
T. Sakamoto, T. Murata, and H. Inomata (1991)
Arch Ophthalmol 109, 1270-1274
   Abstract »    PDF »
The Importance of Antigen Processing in Determinant Selection and of the Cell Membrane as a Reservoir of Processed Antigen.
B. Benacerraf, M.T. Michalek, L.H. Dang, and K.L. Rock (1989)
Cold Spring Harb Symp Quant Biol 54, 293-298
   Abstract »    PDF »
The basis for the immunoregulatory role of macrophages and other accessory cells.
E. Unanue and P. Allen (1987)
Science 236, 551-557
   Abstract »    PDF »
Heritable true fitness and bright birds: a role for parasites?.
W. Hamilton and M Zuk (1982)
Science 218, 384-387
   Abstract »    PDF »
Role of MHC gene products in immune regulation.
B Benacerraf (1981)
Science 212, 1229-1238
   PDF »
A Familial Occurrence of Allergic Bronchopulmonary Aspergillosis.
T. S. GRAVES, J. N. FINK, R. PATTERSON, V. P. KURUP, and G. T. SCANLON (1979)
Ann Intern Med 91, 378-382
   Abstract »    PDF »
Histocompatibility-Linked Immune Response Genes.
B. Benacerraf and H. O. McDevitt (1972)
Science 175, 273-279
   PDF »
Autoimmune Murine Thyroiditis Relation to Histocompatibility (H-2) Type.
A. O. Vladutiu and N. R. Rose (1971)
Science 174, 1137-1139
   Abstract »    PDF »
Immune Responses of Inbred Mice to Repeated Low Doses of Antigen: Relationship to Histocompatibility (H-2) Type.
N. M. Vaz and B. B. Levine (1970)
Science 168, 852-854
   Abstract »    PDF »
Antigenicity: Some Molecular Aspects.
M. Sela (1969)
Science 166, 1365-1374
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)