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Science 28 February 1969:
Vol. 163. no. 3870, pp. 950 - 952
DOI: 10.1126/science.163.3870.950
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Articles

Plague Bacillus: Survival within Host Phagocytes

Werner A. Janssen 1 and Michael J. Surgalla 1

1 Biological Sciences Laboratory, Fort Detrick, Frederick, Maryland 21701

Pasteurella pestis within nelutrophiles and macrophages removed from the peritoneal cavity of guinea pigs dutring experimental plague were shown to be viable by direct microscopic observation of the infected phagocytes incubating in sutitable bacteriologic media. The time-honored hypothesis that the major determinanit of the virulence of the plague bacillius is its ability to resist ingestion by phagocytes mutst be reevaluated.


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Yersinia pestis Type III Secretion System-Dependent Inhibition of Human Polymorphonuclear Leukocyte Function.
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Vaccination with Live Yersinia pestis Primes CD4 and CD8 T Cells That Synergistically Protect against Lethal Pulmonary Y. pestis Infection.
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Effects of Psa and F1 on the Adhesive and Invasive Interactions of Yersinia pestis with Human Respiratory Tract Epithelial Cells..
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Gamma Interferon, Tumor Necrosis Factor Alpha, and Nitric Oxide Synthase 2, Key Elements of Cellular Immunity, Perform Critical Protective Functions during Humoral Defense against Lethal Pulmonary Yersinia pestis Infection..
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Cell-Mediated Protection against Pulmonary Yersinia pestis Infection.
M. A. Parent, K. N. Berggren, L. W. Kummer, L. B. Wilhelm, F. M. Szaba, I. K. Mullarky, and S. T. Smiley (2005)
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Replication of Yersinia pestis in interferon {gamma}-activated macrophages requires ripA, a gene encoded in the pigmentation locus.
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Yersinia Outer Protein P Inhibits CD8 T Cell Priming in the Mouse Infection Model.
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Antibody against V Antigen Prevents Yop-Dependent Growth of Yersinia pestis.
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Interleukin-10 and Inhibition of Innate Immunity to Yersiniae: Roles of Yops and LcrV (V Antigen).
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Molecular Characterization of KatY (Antigen 5), a Thermoregulated Chromosomally Encoded Catalase-Peroxidase of Yersinia pestis.
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