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Science 28 February 1969:
Vol. 163. no. 3870, pp. 937 - 939
DOI: 10.1126/science.163.3870.937
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Articles

Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells

Peter Perlmann 1, Hedvig Perlmann 1, Hans J. Müller-Eberhard 2, and Jorge A. Manni 2

1 Wenner-Gren Institute for Experimental Biology, University of Stockholm, Stockholm, Sweden
2 Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Chromium-51-labeled chicken erythrocytes (E), treated with rabbit anti-Forssman antibody (A) and the first four (C1-4) or the first seven (C1-7) components of human complement (C), released isotope upon exposure to human leukocytes. Isotope release from EACJ-7 cells proceeded more rapidly and was more extensive than that from EACI-3 cells. Lysis of these cells was suppressed by pretreatment of leukocytes with antimycinA. Monocyte-enriched leukocyte preparations affected both types of target cell-complement intermediates, whereas purified lymphocytes lysed EACI-7 cells but not EACI-3 cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibody-Dependent Lymphoid Cell-Mediated Cytotoxicity: No Requirement for Thymus-Derived Lymphocytes.
J. A. Van Boxel, J. D. Stobo, W. E. Paul, and I. Green (1972)
Science 175, 194-196
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Science. ISSN 0036-8075 (print), 1095-9203 (online)