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Science 28 February 1969:
Vol. 163. no. 3870, pp. 931 - 935
DOI: 10.1126/science.163.3870.931
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Articles

Synaptic Activation of an Electrogenic Sodium Pump

Harold Pinsker 1 and Eric R. Kandel 1

1 Departments of Physiology and Psychiatry, New York University Medical School, New York 10016

An identified molluscan interneuron mediates different cholinergic synaptic actions by increasing the conductance of its follower cells to different ions. We have now found that this interneuron also mediates a new class of synaptic actions which does not involve a conductance change but the activation of an electrogenic sodium pump. This synaptic action results in a prolonged inhibitory synaptic potential which is dependent on metabolism and is selectively blocked by cooling and ouabain. In cells which have this synaptic potential, part of the resting membrane potential is also maintained by an electrogenic sodium pump. The same transmitter, acetylcholine, can independently stimulate both a chloride ion conductance and a sodium pump mechanism in the same follower cell by acting on two different postsynaptic receptors.


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