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Science 21 February 1969:
Vol. 163. no. 3869, pp. 826 - 828
DOI: 10.1126/science.163.3869.826
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Articles

Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome

Herbert H. Schaumburg 1, Robert Byck 2, Robert Gerstl 3, and Jan H. Mashman 4

1 Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461
2 Departments of Pharmacology and Rehabilitation Medicine
3 Department of Pharmacology
4 Saul R. Korey Department of Neurology

Monosodium L-glutamate is the cause of the Chinese restaurant syndrome and can precipitate headaches. In appropriate doses it causes burning sensations, facial pressure, and chest pain. These are pharmacological effects obeying a dose-effect relationship. There is considerable variation in oral threshold does among individuals.


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Environmental Illness-Reply.
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Food Allergy.
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Food Allergy.
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JAMA 248, 2627-2631
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Chinese Restaurant Syndrome in an Infant.
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Clinical Pediatrics 19, 705-706
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Migraine, Headache, and Related Conditions--Panel 7.
O. Appenzeller, R. G. Feldman, and A. P. Friedman (1979)
Arch Neurol 36, 784-805
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Migraine: II. Treatment.
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JAMA 239, 2480-2484
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MSG-Reply.
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Saltiness of Monosodium Glutamate And Sodium Intake.
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JAMA 230, 670
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Monosodium Glutamate: Feeding of Large Amounts in Man and Gerbils.
G. Bazzano, J. A. D'Elia, and R. E. Olson (1970)
Science 169, 1208-1209
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Human biological adaptability. The ecological approach in physical anthropology..
G. W. Lasker (1969)
Science 166, 1480-1486
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Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate.
J. W. Olney (1969)
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