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Science 21 February 1969:
Vol. 163. no. 3869, pp. 820 - 821
DOI: 10.1126/science.163.3869.820
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Articles

Hemicholinium-3: Noncholinergic Effects on Squid Axons

Donald T. Frazier 1, Toshio Narahashi 2, and John W. Moore 2

1 Department of Physiology, University of New Mexico School of Medicine, Albuquerque 87106
2 Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27706

Hemicholinium-3, when applied to the inside of a squid axon, is effective in blocking the action potential. This action is not antagonized by the addition of choline or acetylcholine to the perfusate. Voltage-clamp experiments show that hemicholinium-3 depresses both the early transient and late steady-state components of membrane ionic conductances, with a greater effect on the peak transient component.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)