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Science 14 February 1969:
Vol. 163. no. 3868, pp. 691 - 692
DOI: 10.1126/science.163.3868.691
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Articles

Prostaglandin Stimulation of Rat Corticosteroidogenesis

J. D. Flack 1, R. Jessup 1, and P. W. Ramwell 1

1 Worster Foundation for Experimental Biology, Shrewsbury, Massachusetts

Prostaglandins and their C20:ohgr6 fatty acid precursors are present in rat adrenal glands. Small doses of prostaglandins (PGE1, PGE2, or PGF1infin 1.4 to 2.4 micromolar) increased steroidogenesis in the superfused adrenal glands obtained from hypophysectomized rats. This effect was mimicked in part by both adrenocorticotropin and its postulated intracellular intermediate adenosine 3', 5'-cyclic monophosphate; all three responses were inhibited by cycloheximide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Systemic Immune Challenge Activates an Intrinsically Regulated Local Inflammatory Circuit in the Adrenal Gland.
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Endocrinology 149, 1436-1450
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Prostaglandins in Middle Ear Effusions.
J. M. Bernstein, T. Okazaki, and R. E. Reisman (1976)
Arch Otolaryngol Head Neck Surg 102, 257-258
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Prostaglandins, Inflammation, and Asthma.
R. B. Zurier (1974)
Arch Intern Med 133, 101-110
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Substances That Inhibit the Actions of Prostaglandins.
J. H. Sanner (1974)
Arch Intern Med 133, 133-146
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Prostaglandin Receptor Site: Evidence for an Essential Role in the Action of Luteinizing Hormone.
F. A. Kuehl Jr., J. L. Humes, J. Tarnoff, V. J. Cirillo, and E. A. Ham (1970)
Science 169, 883-886
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